The NFL's biggest names under center and a pair of future Hall of Famers set separate career milestones in Week 5 action this weekend.

First, Peyton Manning became just the second quarterback in league history to pass for 500 career touchdowns in Denver's 41-20 win over the Cardinals. The milestone was set on his first of four TD throws on the day. He currently has 503. Brett Favre is the only other QB to have thrown for 500 - ending his career with 508.

In the Sunday night meeting between the Patriots and Bengals, Tom Brady and his offense looked better than it has in recent weeks. In doing so, Brady surpassed 50,000 yards passing for his career, becoming just the sixth player to ever reach that plateau.

Peyton Manning has over 66,000 for his career, second all-time to Favre's 71,838. The 50,000 yard club also includes Dan Marino (3), Drew Brees (4) and John Elway (5).

Jared Wickerham, Getty Images
Jared Wickerham, Getty Images
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