Bronx, NY (Sports Network) - David Ortiz belted a two-run homer for a second straight night, this time going deep off A.J. Burnett in the first inning, part of Boston's 11-6 triumph over the New York Yankees.

J.D. Drew homered and knocked in three runs for the Red Sox, who moved to 7-1 this season against their AL East rival. They also gained a one-game lead in the division by topping the Yankees for a sixth consecutive time, and have won five straight overall.

Carl Crawford and Drew homered in the ninth inning for Boston, which for the first time since 1912 has won its initial five road games against the Yankees.

They were then known as the New York Highlanders and played at Hilltop Park.

Knuckleball specialist Tim Wakefield (3-1) earned the win despite allowing five hits and as many runs over 5 1/3 innings. Alfredo Aceves went the rest of the way for his first save of 2011.

Burnett (6-4) was pounded for seven hits and seven earned runs over 5 2/3 innings.

Francisco Cervelli, replacing an injured Russell Martin (back), went 3-for-3 with two RBI. Derek Jeter moved within 11 hits of 3,000 with an RBI double in the fifth inning, but the Yankees are in danger of being swept in the three- game set.

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