Massive Drugstore Chain Shuttering 142 Locations Nationwide, 5 in New York

Pharmacy closures are ramping up across New York State, with seven permanently closing their doors.

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With May already being a terrible month for drugstore chains, the last thing customers want to hear is that their local pharmacy is going under.

Just last week, Walgreens confirmed it was closing four additional locations across New York, bringing the total number to 10 so far this year.

For another chain, the writing has been on the wall for over a month that it was going out of business entirely.

Rite Aid to Close 100 More Stores - How Many in New York?

The drugstore chain filed for bankruptcy earlier this month and announced plans to shutter all locations nationally if a buyer isn't found.

The following week, Rite Aid announced plans to close at least 68 locations nationwide, including 2 in New York.

• 9 Broad Street, Salamanca
• 1070 Genesee Street, Buffalo

The chain has since revised its intended closures to 142, which amounts to over 10% of its portfolio.  This includes an additional 5 in the Empire State.

• 5901 Bay Parkway, Brooklyn
• 55-60 Myrtle Avenue, Ridgewood
• 8222 18th Avenue, Brooklyn
• 50-15 Roosevelt Avenue, Woodside
• 10601 60-26 Woodside Avenue, Woodside

While Rite Aid's 14 Central New York locations haven't been mentioned, their fate is still undecided.

The chain is undergoing Chapter 11 bankruptcy proceedings, where it is in the process of selling and closing all of its stores. Next month, the company is expected to start issuing layoff notices to its employees.

If Rite Aid is sold, the future buyer will get to decide what to do with them. If no buyer is found, these stores will cease to exist.

To date, there are 1,240 Rite Aids in the United States.

Other Chains and Companies Struggling in 2025

Pharmacies aside, several national companies are also struggling to stay afloat - even banks.  TD Bank confirmed it was closing 40 locations nationwide, including 5 in the Empire State.

Denny's is also downsizing and recently shuttered 2 locations in Central New York.

Read More: 30 Big Chains That Are Closing or Have Closed Locations in 2025

Closures have also come on the local level. Recently, the Clinton Community Pool confirmed its demise after a 60-year run.

And in just a few weeks, About Hair in Whitesboro will permanently close.

Meanwhile, many are watching Destiny USA as rumors swirl the massive mall could go under after it defaulted on its mortgage.

Check out the growing list below to see what other restaurants, stores, and businesses the Mohawk Valley lost in 2025.