By LINDSEY BAHR, AP Film Writer

Never underestimate your friendly neighborhood Spider-Man, even with a mutating virus afoot.

Despite rising concerns over the omicron variant, "Spider-Man: No Way Home" not only shattered pandemic-era box office records; it became the third best opening of all time behind "Avengers: Endgame" and "Avengers: Infinity War."

Studio estimates on Sunday show the Sony and Marvel blockbuster grossed a stunning $253 million in ticket sales from 4,325 North American locations.

The web-slinger's success couldn't have come sooner for a movie business that has had a rollercoaster 2021 and could be headed for a difficult start to 2022 as omicron variant of the coronavirus forces more and more event cancellations.

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