Robinson Cano had a grand slam in the New York's seven-run third inning as the Yankees bounced back with a 12-3 win over the Orioles on Wednesday after dropping the first two games of the series.

Derek Jeter added three hits and three RBI's, Jayson Nix had three hits and two runs scored and Curtis Granderson added his 29th homer of the year, a first inning solo shot off Zach Britton.

A dozen runs was well more than Phil Hughes needed, yielding just one run on nine hits through six innings to up his record to 11-8.

Britton (1-1) never made it out of the third, working 2 2/3 innings after seven runs. Kevin Gregg's relief outing didn't go much better, giving up five hits and four runs - including Cano's slam, in 1 1/3 innings.

New Yankee Casey McGehee, acquired from the Pirates this week, made his debut at first base and while he didn't pick up his first hit in pinstripes, he did have two walks, two runs scored and an RBI.

Also, Joba Chamberlain made his first appearance in over a year, allowing two runs on four hits and a walk in 1 2/3 innings. Chamberlain last pitched in June of the 2011 season before undergoing Tommy John surgery. He then suffered a nasty ankle injury while jumping on a trampoline in the spring.

The Yanks' lead over Baltimore in the AL East is now at 6.5 games. New York will host a series with the Mariners in the Bronx beginning Friday night.